EXTERNAL PROFILES
Professor
Dr. Md. Rafiqul Islam
Major Field of Specialization: My specialization centers on the development of advanced transdermal drug delivery systems (TDDS) using biocompatible ionic liquids (ILs) and hybrid nanostructures for targeted therapies in oncology and diabetes management. I design and evaluate platforms such as IL-in-oil (IL/O) microemulsions, solid-in-oil nanoparticles, and polymer composites to enhance drug solubility, skin permeation, and therapeutic efficacy. A core focus of my research is synthesizing choline-based ILs from GRAS components such as amino acids, carboxylic acids, and fatty acids. These ILs serve as permeation enhancers and carriers for poorly soluble drugs such as paclitaxel, methotrexate, OVA, acyclovir, and insulin. I formulate IL/O microemulsions and solid-in-oil systems that enable non-invasive delivery of these agents, optimizing physicochemical properties through DLS, HPLC, and rheological analysis. For diabetes treatment, I explore transdermal insulin delivery using IL-based systems that bypass gastrointestinal degradation and improve patient compliance. These formulations are engineered to maintain insulin bioactivity, enhance skin permeation, and provide sustained-release profiles. Polymer composites incorporating ILs are also developed to create flexible, adhesive patches suitable for chronic use. Mechanistic studies using confocal microscopy, DSC, and ATR-FTIR reveal IL–skin interactions and barrier modulation. In vivo evaluations in tumor-bearing and diabetic murine models assess therapeutic outcomes, including modulation of cytokines, immune cell activation, and glycemic control. In parallel with my research, I actively contribute to science education by developing inclusive, multimodal curricula in biochemical engineering and drug delivery for younger learners. Overall, my field integrates ionic liquid chemistry, TDDS, IL/O microemulsions, solid-in-oil nanoparticles, polymer composites, and translational strategies for cancer and diabetes care, bridging cutting-edge research with real-world therapeutic impact.
Applied Chemistry and Chemical Engineering
BIOGRAPHY
RESEARCH INTERESTS
2017 - 2020
Ph.D
Applied Chemistry
Kyushu University, Japan
2008 - 2009
MS
Applied Chemistry and Chemical Engineering
Dhaka University
2002 - 2008
BSc
Applied Chemistry and Chemical Engineering
Dhaka University
1999 - 2001
HSC
Science
Govt. Ashek Mahmud College
1994 - 1999
SSC
Science
Rajibpur Pilot High School
Last updated on 2026-09-01 06:07:59
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AWARDS AND ACHIEVEMENTS
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2025
Journal
Assessment of Tomato Genotypes Using Morpho-physical and Biochemical Traits in Southern Bangladesh
Authors: Hossain, Najmul and Rubel, Mehede Hassan and Islam, Md Rafiqul and Jhan, Pijush Kanti and Kamal, Md Mostofa and Anjum, Kazi Ishrat and Nuruzzaman, Md Mohammaed and Moury, Papia Rahman
Journal: Research in Agriculture Livestock and Fisheries
DOI: 10.3329/ralf.v12i1.81528001.
2024
Journal
Occurrence and spatial distribution of microplastics in water and sediments of Hatiya Island, Bangladesh and their risk assessment
Authors: Fardullah, Md and Hossain, Md Tanvir and Islam, Mohammad Saimon and Islam, Md Rafiqul and Rahman, Md Rakibur and Akther, Khadigha and Uddin, Azad and Morshed, Shamsul and Sultana, Nahid and Alam, Md Ashraful and others
Journal: Journal of Environmental Management
DOI: 10.1016/j.jenvman.2024.122697
2023
Journal
Modification with conventional surfactants to improve a lipid-based ionic-liquid-associated transcutaneous anticancer vaccine
Authors: Uddin, Shihab and Islam, Md Rafiqul and Moshikur, Rahman Md and Wakabayashi, Rie and Moniruzzaman, Muhammad and Goto, Masahiro
Journal: Molecules
DOI: 10.3390/molecules28072969.
2022
Journal
Color fastness and tensile properties of cotton fabric dyed with extract from Albizia procera sawdust
Authors: Sultana, Shahin and Akter, Khaleda and Sarker, Md Khabir Uddin and Bhuiyan, Riyadh Hossen and Haque, Mohammad Majedul and Islam, Md Rafiqul
Journal: Fibers and Polymers
DOI: 10.1007/s12221-022-4707-x.
2022
Journal
Transdermal delivery of antigenic protein using ionic liquid-based nanocarriers for tumor immunotherapy
Authors: Uddin, Shihab and Islam, Md Rafiqul and Md Moshikur, Rahman and Wakabayashi, Rie and Kamiya, Noriho and Moniruzzaman, Muhammad and Goto, Masahiro
Journal: ACS Applied Bio Materials
DOI: 10.1021/acsabm.2c00061
2021
Journal
Insulin transdermal delivery system for diabetes treatment using a biocompatible ionic liquid-based microemulsion
Authors: Islam, Md Rafiqul and Uddin, Shihab and Chowdhury, Md Raihan and Wakabayashi, Rie and Moniruzzaman, Muhammad and Goto, Masahiro
Journal: ACS Applied Materials \& Interfaces
DOI: 10.1021/acsami.1c11533.
2021
Journal
Lipid-based ionic-liquid-mediated nanodispersions as biocompatible carriers for the enhanced transdermal delivery of a peptide drug
Authors: Uddin, Shihab and Islam, Md Rafiqul and Chowdhury, Md Raihan and Wakabayashi, Rie and Kamiya, Noriho and Moniruzzaman, Muhammad and Goto, Masahiro
Journal: ACS applied bio materials
DOI: 10.1021/acsabm.1c00563
2020
Journal
Choline and amino acid based biocompatible ionic liquid mediated transdermal delivery of the sparingly soluble drug acyclovir
Authors: Islam, Md Rafiqul and Chowdhury, Md Raihan and Wakabayashi, Rie and Tahara, Yoshiro and Kamiya, Noriho and Moniruzzaman, Muhammad and Goto, Masahiro
Journal: International journal of pharmaceutics
DOI: 10.1016/j.ijpharm.2020.119335.
2020
Journal
Ionic liquid-in-oil microemulsions prepared with biocompatible choline carboxylic acids for improving the transdermal delivery of a sparingly soluble drug
Authors: Islam, Md Rafiqul and Chowdhury, Md Raihan and Wakabayashi, Rie and Kamiya, Noriho and Moniruzzaman, Muhammad and Goto, Masahiro
Journal: Pharmaceutics
DOI: 10.3390/pharmaceutics12040392.
2018
Journal
Evaluation of mechanical properties of both benzoyl peroxide treated and untreated teak sawdust reinforced high density polyethylene composites
Authors: Akter, Taslima and Nur, Husna P and Sultana, Shahin and Islam, Md Rafiqul and Abedin, Md Joynal and Islam, Zahidul
Journal: Cellulose
DOI: 10.1007/s10570-017-1620-3.
2017
Journal
Chemical and microbial analysis of potable water in public water supply of greater Noakhali, Bangladesh
Authors: Anjum, R and Khan, AS and Islam, MZ and Islam, Md Rafiqul and Bahadur, NM
Journal: Int. J. Sci. Eng. Res
2015
Journal
Preparation and Characterization of Tin Oxide based Transparent Conducting Coating for Solar Cell Application
Authors: Sharker, Komol Kanta and Khan, Mubarak A and Khan, Shauk MM and Islam, Md Rafiqul
Journal: International Journal of Thin Films Science and Technology
DOI: 10.12785/ijtfst/040315
2012
Journal
Fabrication and characterization of jute fabric-reinforced PVC-based composite
Authors: Khan, Ruhul A and Khan, Mubarak A and Zaman, Haydar U and Parvin, Fahmida and Islam, Towhidul and Nigar, Farah and Islam, Md Rafiqul and Saha, Suvasree and Mustafa, AI
Journal: Journal of Thermoplastic Composite Materials
DOI: 10.1177/0892705711404726
2011
Journal
Fabrication and mechanical characterization of jute fabrics: reinforced polyvinyl chloride/polypropylene hybrid composites
Authors: Islam, Md Rafiqul and Islam, Towhidul and Nigar, Farah and Saha, Suvasree and Tapash, Arifuzzaman and Sharmin, Nusrat and Dey, Kamol and Mustafa, AI and Khan, Ruhul A and Khan, Mubarak A and others
Journal: International Journal of Polymeric Materials
DOI: 10.1080/00914037.2010.531822
2011
Journal
Comparative studies of mechanical and interfacial properties between jute fiber/PVC and E-glass fiber/PVC composites
Authors: Khan, Ruhul A and Sharmin, Nusrat and Khan, MA and Das, AK and Dey, Kamol and Saha, Suvasree and Islam, Towhidul and Islam, Md Rafiqul and Nigar, Farah and Sarker, Bapi and others
Journal: Polymer-Plastics Technology and Engineering
DOI: 10.1080036025592010531422
2010
Journal
Effect of UV and gamma radiation on the mechanical and degradation properties of LLDPE-clay composites
Authors: Khan, Mubarak Ahmad and Islam, Rafiqul and Islam, Towhidul and Nigar, Farah and Rahman, Nazia and Rahman, M Mizanur and Mustafa, AI
Journal: Advanced Materials Research
DOI: 10.4028/www.scientific.net/AMR.123-125.415
2010
Journal
Effect of the incorporation of PVC on the mechanical properties of the jute-reinforced LLDPE composite
Authors: Khan, Ruhul A and Zaman, Haydar U and Khan, Mubarak A and Nigar, Farah and Islam, Towhidul and Islam, Md Rafiqul and Saha, Suvasree and Rahman, M Mizanur and Mustafa, AI and Gafur, MA
Journal: Polymer-Plastics Technology and Engineering
DOI: 10.1080/03602551003749544
2021
Book Chapter
Book Name: Application of ionic liquids in drug delivery
Chapter Title: Ionic Liquid-Based Oral Drug Delivery
Authors: Islam, Md Rafiqul and Goto, Masahiro
DOI: 10.1007/978-981-16-4365-1
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- Institutional Email: rafiq.acce@nstu.edu.bd
- Personal Email: rafiq.acce@nstu.edu.bd
- Mobile number: 01755026707
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- PABX:N/A
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Department
Applied Chemistry and Chemical Engineering
Noakhali Science and Technology University